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１９９１年１月～１９９４年７月以异环磷酰胺为主（ＩＭＶＤ方案）治疗晚期复发性或／和转移性癌２２例。男１４例，女８例。年龄２５～７０岁，中位数５２岁。治疗客观缓解率６８．２％，其中ＣＲ２２．７％，ＰＲ４５．５％。１８例至今已生存１～２．５年，１５例仍处于ＣＲ或ＰＲ。毒副反应主要是轻度恶心，镜下血尿，脱发和骨髓抑制。１１例化疗前后加用Ｇ—ＣＳＦ，有骨髓保护作用。本组无因治疗而引起的死亡。作者认为以ＩＦＯ为主的化疗疗效满意，毒性较低。
From 1991 to July 1994, 22 cases of advanced recurrent or metastatic carcinoma were treated with ifosfamide (IMVD regimen). There were 14 males and 8 females. Age 25 to 70 years, median 52 years old. The objective response rate of treatment was 68.2%, including CR 22.7% and PR 45.5%. 18 cases have survived for 1 to 2.5 years so far, and 15 cases are still in CR or PR. The toxicities were mainly mild nausea, microscopic hematuria, hair loss and myelosuppression. Eleven patients were treated with G-CSF before and after chemotherapy, which had bone marrow protection. There were no deaths due to treatment in this group. The authors believe that IFO-based chemotherapy is satisfactory and less toxic.