目的：研究氟哌酸胶囊和栓剂在人体中的药代动力学参数和生物利用度。方法：对８名健康男性志愿者分别单次给药氟哌酸胶囊和栓剂，采用紫外分光光度法测定了该药尿液中的浓度（紫外测定波长为３３６ｎｍ）。结果：两种剂型的主要药代动力学参数计算如下：Ｔ１／２（胶）＝３４９±０３４ｈ，Ｔ１／２（栓）＝３４４±０３９ｈ，Ｔｍ（胶）＝２０４±０１５ｈ．Ｔｍ（栓）＝２０１±０１１ｈ，ＡＵＣ（胶）＝１８３９２±８３２μｇ／ｍｌ·ｈ，ＡＵＣ（栓）＝１６８５８±１０９９μｇ／ｍｌ·ｈ．氟哌酸栓剂的相对生物利用度为９１７２±５７０％（以其胶囊为参比标准品）。结论：通过ｔ检验显示该药的两种剂型的药代动力学参数和生物利用度是相近的。 OBJECTIVE: To study the pharmacokinetic parameters and bioavailability of norfloxacin capsules and suppositories in humans. Methods: Eight healthy male volunteers were given a single dose of norfloxacin capsule and suppository. The urine concentration (UV detection wavelength was 336nm) was determined by ultraviolet spectrophotometry. RESULTS: The main pharmacokinetic parameters of the two formulations were calculated as follows: T1 / 2 = 3.49 ± 0.34h, T1 / 2 = 3.44 ± 0.39h, Tm = 204 ± 015h. Tm = 201 ± 011h, AUC = 18392 ± 832μg / ml · h, and AUC was = 15858 ± 1099μg / ml · h. The relative bioavailability of norfloxacin suppository was 9172 ± 570% (with its capsule as reference standard). CONCLUSIONS: The t test showed that the pharmacokinetic parameters and bioavailability of the two formulations of the drug were similar.