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有作者报道过长期口服贯序法避孕药(Oracon)引起年轻妇女患子宫内膜腺癌。Lucans1974年温习了子宫内膜腺癌与病人内分泌代谢改变的关系,指出连续使用雌激素刺激子宫内膜,不加用孕激素对抗,会使良性增殖变成囊性增生过长,腺型增生过长,与不同程度的不典型增生包括子宫内膜腺癌。炔雌醇(E、E)比乙底酚的作用强25倍,最近认为孕妇服乙底酚后会牵涉到后代患阴道腺癌与子宫内膜腺癌。
It has been reported that long-term Oracon causes young women to develop endometrial adenocarcinoma. Lucans in 1974, a comparison of the death of patients with malignant and the history of the changes in the body of patients, pointed out that the continuous use of estrogen to stimulate the endometrium, without the use of progesterone confrontation, will benign proliferation into cystic hyperplasia, hyperplasia Long, with varying degrees of dysplasia including endometrial adenocarcinoma. Ethinylestradiol (E, E) is 25 times more potent than ethylphe- nol and has recently been shown to be associated with vaginal adenocarcinoma and endometrial adenocarcinoma in the offspring of pregnant women after taking it.