论文部分内容阅读
对阿司匹林、非那西汀(或扑热息痛)、咖啡因的分光光度分析溶剂选择,推荐应用1%氯乙酸无水乙醇以满足同时溶解又避免阿司匹林水解这二方面的问题。实验表明,上述三组份药物在该溶剂内基本稳定。高波数区均满足紫外分光光度分析溶剂的要求,不足之处在于提供信息量较少。且溶剂温度系数较大。本文提出的另一种方法是0.2N NaOH完全水解阿司匹林,在pH6.5磷酸盐缓冲溶液内测定水杨酸—钠盐、非那西汀(或扑热息痛)和咖啡因的紫外光谱。实验表明:在本文所采用的水解条件下,阿司匹林水解完全,而其它药物几乎不受影响。本法的误差,是由制剂中可能存在的水杨酸、pH6.5缓冲液条件下
Aspirin, phenacetin (or paracetamol), caffeine spectrophotometric solvent selection, recommended the use of 1% anhydrous ethanol chloroacetic acid to meet the simultaneous dissolution and avoid aspirin hydrolysis of these two issues. Experiments show that the three-component drugs in the solvent basically stable. High wave number of areas are to meet the requirements of UV spectrophotometric solvent, the downside is to provide less information. And the solvent temperature coefficient larger. An alternative method presented here is complete hydrolysis of aspirin with 0.2 N NaOH and UV spectroscopy of salicylate-sodium salt, phenacetin (or paracetamol) and caffeine in pH 6.5 phosphate buffered saline. Experiments show that: hydrolysis conditions used in this article, aspirin completely hydrolyzed, and other drugs almost unaffected. The error of this method is based on the possible presence of salicylic acid in the formulation at pH6.5 buffer conditions