Targeting sphingosine-1-phosphate signaling for cancer therapy

来源 :中国科学：生命科学英文版 | 被引量 : 0次 | 上传用户：wangjue419

【摘要】

：

Sphingosine-1-phosphate(S1P) is a potent pleotropic bioactive lipid mediator involved in immune cell trafficking, cell survival,cell proliferation, cell migrati

【作者】

：

Zuoquan Xie Hong Liu Meiyu Gen

【机构】

：

DivisionofAntitumorPharmacology,DivisionofChemistry

【出处】

：

中国科学：生命科学英文版

【发表日期】

：

2017年6期

【关键词】

：

1-磷酸鞘氨醇靶向治疗信号癌症自身免疫性疾病免疫细胞受体激动剂细胞存活率 sphingosine-1-phosphate sphingosine

【基金项目】

：

financial support from the National Natural Science Foundation of China （91229204）,the Major Project of the Chinese National Programs for Fundamental Research and Development （2015CB910304）

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Sphingosine-1-phosphate(S1P) is a potent pleotropic bioactive lipid mediator involved in immune cell trafficking, cell survival,cell proliferation, cell migration, angiogenesis and many other cellular processes. S1 P either activates S1 P receptors(S1PR1-

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Targeting sphingosine-1-phosphate signaling for cancer therapy

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