CHIMERIC相关论文
Programmed cell death protein-1 inhibitor combined with chimeric antigen receptor T cells in the tre
BACKGROUND Chimeric antigen receptor T cell(CART)therapy has benefited many refractory lymphoma patients,but some patien......
Relapsed or refractory non-Hodgkin’s lymphomas,especially diffuse large B-cell lymphoma as well as relapsed or refracto......
New approaches to cancer immunotherapy have been developed, showing the ability to harness the immune system to treat an......
Suppression of HIV-1 Integration by Targeting HIV-1 Integrase for Degradation with A Chimeric Ubiqui
Human immunodeficiency virus(HIV) attacks human immune system and causes life-threatening acquired immune deficiency syn......
Interleukin-2 (IL-2 ) 是一个重要 immunoregulatory 因素。在在 IL-2 和它的受体之间的相互作用以后，细胞内部的信号分子被激活并......
The variable domain of heavy chain (VH) and light chain (VL) genes of anti-CD20 monoclonal antibody HL47 were cloned fro......
Genetic engineering of T cells with chimeric antigen receptors for hematological malignancy immunoth
The host immune system plays an instrumental role in the surveillance and elimination of tumors by recognizing and destr......
Introducing chimeric antigen receptor into immune cells against malignancies has contributed to a revolutionary innovati......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
With the development of deep sequencing and bioinformatics technology, a large number of products produced by abnormal R......
microRNA是一类长约24个碱基的非编码RNA，其广泛表达在各种生物体内，发挥重要的调节功能，在免疫系统中，亦有报道认为其参与了免疫细胞......
Glioma is the most common and destructive tumor of primary brain tumor types in the central nervous system.After compreh......
Chimeric antigen receptor(CAR)T-cell therapy is an effective new treatment strategy for hematologic malignancies.The suc......
ＰＣＲ扩增抗ＣＤ３单抗轻链可变区和重链可变片段基因，将其重组到Ｆａｂ’表达载体中，构建成抗ＣＤ３嵌合抗体Ｆａｂ’表达载体，转化大肠杆菌１６９Ｃ９进行可溶性表达。产物经......
Gene-modified leucoconcentrate for personalized ex vivo gene therapy in a mini pig model of moderate
We previously demonstrated that gene-modified umbilical cord blood mononuclear cells overexpressing a combination of rec......
为构建能同时表达抗人CD28嵌合重链和嵌合轻链基因的双启动子杆状病毒转移载体,利用PCR法扩增出抗人CD28鼠源性单抗的可变区基因和......
To construct and express a human-mouse chimeric antibody against human bladder cancer. Method: The variable region genes......
Background:Chimeric antigen receptor-engineered T-cell(CAR-T)therapy is a newly developed immunotherapy used in the trea......
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ＴｕｍｏｒｒａｄｉｏｉｍｍｕｎｏｉｍａｇｉｎｇｏｆｃｈｉｍｅｒｉｃａｎｔｉｂｏｄｙｉｎｎｕｄｅｍｉｃｅｗｉｔｈｈｅｐａｔｏｍａｘｅｎｏｇｒａｆｔＧＯＮＧＹｉ１，ＬＩＵＫａｎｇＤａ１，ＺＨＯＵＧｅ１，ＸＵＥＱｉｏｎｇ１，ＣＨＥＮＳｈａｏＬｉａｎｇ.........
Effects of chimeric molecule of recombinant Dsg3EC1-2 with toxin PE40 on T and B lymphocytes in Pemp
Objective:To observe the effects of the recombinant chimeric toxin Dsg3EC1-2PE40 on T and B lymphocytes isolated from Pe......
嵌合体纤溶酶是采用基因重组技术或化学偶联的方法将纤溶酶与其它的功能多肽(含有酶原结构域,具有抗凝血酶、抗血小板聚集活性,能......
ＣＤ４ｍｏｌｅｃｕｌｅｉｓａｓｐｅｃｉａｌｍａｒｋｅｒｏｆｔｈｅｈｅｌｐｅｒＴｌｙｍｐｈｏｃｙｔｅ（ＴＨ）ａｎｄｄｅｌａｙｅｄｔｙｐｅｈｙｐｅｒｓｅｎｓｉｔｉｖｉｔｙＴｌｙｍｐｈｏｃｙｔｅ（ＴＤＴＨ）ａｓｗｅｌａｓａｄｉｆｅｒｅｎｔｉａｔｉｏｎｍａｒ.........
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Relevant nursing measures for the adverse reactions associated with chimeric antigen receptor T cell
Objective: Cytokine release syndrome (CRS) and tumor lysis syndrome (TLS) that occur after chimeric antigen receptor T (......
Relapses remain a major concern in acute leukemia. It is well known that leukemia stem cells(LSCs) hide in hematopoietic......
0 ＩｎｔｒｏｄｕｃｔｉｏｎＢｒｅｅｄｉｎｇｐｅｓｔｒｅｓｉｓｔａｎｔｐｌａｎｔｓｕｓｉｎｇｐｌａｎｔｇｅｎｅｔｉｃｅｎｇｉｎｅｅｒｉｎｇｔｅｃｈｎｉｑｕｅｉｓａｎｅｆｆｅｃｔｉｖｅｓｔｒａｔｅｇｙｉｎｔｈｅｉｎｔｅｇｒａｔｅｄｐｅｓｔｍａｎａｇｅｍ?........
Cancer is one of the leading causes of death worldwide. Recent advances in cellular therapy have demonstrated that this ......
Adoptive cell therapy using chimeric antigen receptor T (CAR-T) cells, which is a promising cancer immunotherapy strateg......
Distinct Transforming Activity of ABL Family Tyrosine Kinase Oncogenes Is Induced by Their C-Termina
The TEL/ARG oncogene is similar in structure to the TEL/ABL fusion found in human leukemia, however, we have demonstrate......
Rejection of Experimental Hodgkins Lymphoma by T-Cells Engineered with a CD19 Chimeric Antigen Recep
T cells engineered to express chimeric antigen receptors (CARs) combining an external antibody binding domain with the C......
Cancer immunotherapy has finally joined the pillars of cancer treatment—surgery, radiation, chemotherapy, hormonal ther......
Tumor immunity proceeds through multiple processes,which consist of antigen presentation by antigen presenting cells(APC......
AIM:To investigate the contribution of bone marrow(BM) cells to hepatic fibrosis.METHODS:To establish a model of chimeri......
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As a rapidly progressing field in oncology,the adoptive transfer of T cells that have been genetically modified with chi......
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Hepatitis B virus (HBV) infection seriously affects human health. Stable and reliable animal models of HBV infection bea......
Claudin 18.2(CLDN18.2)is a tight-junction protein.CLDN18.2-targeting strategy has cut a striking figure in CLDN18.2 posi......
Identification of a Native Novel Oncolytic Immunoglobulin on Exfoliated Colon Epithelial Cells: A Bi
Understanding the nature of cell surface markers on exfoliated colonic cells is a crucial step in establishing criteria ......
