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慢性淋巴细胞白血病(慢淋)是一种低度恶性淋巴细胞克隆增殖性疾病,主要累及B 淋巴细胞。近年来,慢淋的细胞遗传学研究受到重视,普遍采用了多克隆B 细胞丝裂原(PBAs)进行研究,使慢淋染色体异常检出率大大提高,发现了一些规律性变化,为临床估计疗效、判断预后和深入研究发病机理积累了不少有价值的资料,兹综述如下。一、慢淋染色体研究方法学的重要进展尽管七十年代垃带技术的问世,染色体制备技术的提高,发现了慢粒和一些类型的急白
Chronic lymphocytic leukemia (CLL) is a low grade malignant lymphoproliferative disease that mainly affects B lymphocytes. In recent years, attention has been paid to the research on CELLULAR GENETICOLOGY in CLL. Polyclonal B-cell mitogen (PBAs) have been widely used in this study. The detection rate of CLL anomalies has been greatly increased and some regular changes have been found, Curative effect, prognosis and in-depth study of the pathogenesis has accumulated a lot of valuable information, are summarized below. First, the important progress of Clerical Methodology Although the introduction of tape technology in the seventies, the improvement of chromosome preparation technology, found that CML and some types of rapid white