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目的 探讨脑卒中急性期患者血清和脑脊液 (CSF)中游离氨基酸 (FAA)含量变化及其与临床的关系。方法 对 2 8例脑出血和 30例脑梗死患者于急性期测定血清十种氨基酸 (AA)含量 ,选择 6 5例正常人作为对照组 :对 14例脑出血急性期患者和 12例正常人测定CSF中十种AA含量。结果 (1)脑梗死组和脑出血组血清中谷氨酸 (G1u)、门冬氨酸 (Asp)含量显著高于对照组 (P <0 0 1) ,牛磺酸 (Tau)、甘氨酸 (G1y)低与对照组。 (2 )脑出血患者CSF中G1u、Asp明显高于对照组 (P <0 0 1)。结论 动物试验资料表明 ,兴奋性氨基酸 (EEAs)兴奋毒性作用是脑卒中后对脑组织损害的重要病理机制之一 ,本研究从临床角度支持该学说
Objective To investigate the changes of free amino acids (FAA) in serum and cerebrospinal fluid (CSF) in patients with acute stroke and their clinical significance. Methods A total of 28 patients with cerebral hemorrhage and 30 patients with cerebral infarction were enrolled in this study. Acute serum creatinine (AA) levels were measured in 65 patients with normal cerebral hemorrhage. Sixty-five normal subjects were selected as control group. 14 acute cerebral hemorrhage patients and 12 normal controls CSF ten kinds of AA content. Results (1) Serum levels of glutamate (G1u) and aspartate (Asp) in cerebral infarction group and cerebral hemorrhage group were significantly higher than those in control group (P <0.01), taurine (Tau), glycine ) Low and control group. (2) The CSF G1u and Asp in patients with ICH were significantly higher than those in the control group (P <0.01). Conclusion The data from animal experiments show that the excitotoxicity of excitatory amino acids (EEAs) is one of the important pathological mechanisms of brain damage after stroke. This study supports the theory from a clinical perspective