Synthesis of Bis-N-squaramidoacids and their Applications to Asymmetric Reduction of Prochiral Keton

来源 :Chinese Chemical Letters | 被引量 : 0次 | 上传用户:fenghuirong
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A series of novel bis-squaramidoacid ligands were prepared. Prochiral ketone and diketones were direct reduced by borane in the presence of these ligands giving secondary alcohol products with enantiomeric excesses up to 64.2% for w-bromoacetophenone and 90.0% for 1, 6-diphenyl-1, 6-hexanedione. A series of novel bis-squaramidoacid ligands were prepared. Prochiral ketone and diketones were direct reduced by borane in the presence of these ligands giving secondary alcohol products with enantiomeric excesses up to 64.2% for w-bromoacetophenone and 90.0% for 1, 6-diphenyl -1, 6-hexanedione.
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