论文部分内容阅读
目的:利用Meta分析人乳头瘤病毒(HPV)相关感染与宫颈上皮内瘤变(CIN)及宫颈癌发病风险的相关性。方法:检索2000-2012年中国知网、维普、万方等科技期刊网已发表的CIN及宫颈癌与HPV感染相互关系的有关文献,制定纳入标准,筛选HPV相关感染与宫颈相关疾病发病风险的有关统计研究。结果:将14篇文献数据进行分析,统计各疾病累计病例数及相应HPV感染率,累计对照病例数及相应HPV感染率;分别进行Meta分析,结果HPV与CINⅠ的OR值为5.19[4.53,5.95];HPV与CINⅡ的OR值为11.39[9.25,14.03];HPV与CINⅢ的OR值为22.45[15.96,31.57];HPV与宫颈癌的OR值为24.04[16.14,35.85]。结论:宫颈相关疾病发病率与HPV的感染高度相关,HPV感染增加了宫颈相关疾病的发病危险性。
Objective: To analyze the correlation between human papillomavirus (HPV) infection and cervical intraepithelial neoplasia (CIN) and the risk of cervical cancer by Meta. Methods: The published literature about the relationship between CIN and cervical cancer and HPV infection published in CNKI, VIP, Wanfang and other scientific journals from 2000 to 2012 was screened out to include criteria for screening HPV-associated infections and the risk of cervical-related diseases About statistical research. Results: The data of 14 literatures were analyzed, the cumulative number of cases and the corresponding HPV infection rates, the cumulative number of control cases and the corresponding HPV infection rate were calculated. Meta-analysis was performed respectively. The OR of HPV and CINⅠwas 5.19 [4.53, 5.95 The OR of HPV and CINⅡwas 11.39 [9.25,14.03]. The OR of HPV and CINⅢwas 22.45 [15.96,31.57]. The OR of HPV and cervical cancer was 24.04 [16.14,35.85]. CONCLUSIONS: The incidence of cervical-related diseases is highly correlated with HPV infection, which increases the risk of developing cervical-related diseases.