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目的 :检测未经治疗梅毒患者外周血淋巴细胞亚群 ,并探讨其临床意义。方法 :应用流式细胞仪检测 36例 HIV阴性未经治疗的二期及隐性梅毒患者外周血淋巴细胞亚群及 NK淋巴细胞 ,并与 30例健康人群的检测结果相对照。结果 :患者 CD3、CD4 及 NK淋巴细胞与健康人群的检测结果相比差异均无显著性 (P>0 .0 5 ) ,而患者 CD8淋巴细胞明显高于对照组 ,差异有非常显著性 (P<0 .0 0 1) ,CD4 / CD8的比率明显低于对照组 ,差异有非常显著性 (P<0 .0 0 1) ;RPR滴度为 1∶ 2～ 1∶ 8的梅毒患者 CD3淋巴细胞的比例高于对照组 ,差异有显著性 (P<0 .0 5 ) ;二期与隐性梅毒患者之间以及不同 RPR滴度梅毒患者之间 T淋巴细胞亚群及 NK淋巴细胞差异均无显著性 (P>0 .0 5 )。结论 :未经治疗的梅毒患者外周血存在细胞免疫不平衡 ,CD8明显升高可能降低机体抵抗和清除梅毒螺旋体感染的能力。
Objective: To detect the peripheral blood lymphocyte subsets of untreated syphilis and to explore its clinical significance. Methods: Flow Cytometry was used to detect peripheral blood lymphocyte subsets and NK lymphocytes in 36 patients with HIV-negative second-stage and latent syphilis and compared with the results of 30 healthy people. Results: There were no significant differences in the detection results of CD3, CD4 and NK lymphocytes among healthy subjects (P> 0.05), while the level of CD8 lymphocytes in patients was significantly higher than that of the control group (P <0.001), the ratio of CD4 / CD8 was significantly lower than that of the control group, the difference was significant (P <0.01); CD3 lymphocytes of syphilis with RPR titer of 1: 2 to 1: 8 (P <0.05). The differences of T lymphocyte subsets and NK lymphocytes between patients with latent syphilis and patients with syphilis with different RPR titer No significant (P> 0.05). Conclusion: Untreated syphilis in patients with peripheral blood cell imbalance exists imbalance, CD8 significantly increased may reduce the body’s resistance and the ability to clear Treponema pallidum infection.