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采用结扎大鼠冠脉造成急性心肌缺血模型 ,观察了络泰 (三七总皂甙的新剂型 )抗实验性心肌缺血作用。结果表明 ,络泰对大鼠实验性急性心肌缺血有一定程度的保护作用 ,本品 5 0mg/kg显著减少心电图S T段的上移 (P <0 0 1) :络泰 5mg/kg、5 0mg/kg和 10 0mg/kg均显著降低血清CPK(P <0 0 5 ,P<0 0 1) ;在缩小心肌梗塞范围方面也有一定作用 ,但统计学上没有显著性。络泰三个剂量组能显著提高SOD活性 (P <0 0 1) ,降低MDA水平 (P <0 0 5 ) ;本品 5 0mg/kg和 10 0mg/kg还能显著增加心肌缺血时血中PGI2 水平 (P <0 0 5 ) ,提示络泰对心肌缺血的保护作用与抗脂质过氧化作用有关 ,其促进PGI2 合成作用可能与其抗心肌缺血有关
The rat model of acute myocardial ischemia induced by ligation of the coronary artery was used to observe the effect of Luotai (the new formulation of Panax notoginseng saponins) on experimental myocardial ischemia. The results showed that Luotai had a certain degree of protective effect on experimental acute myocardial ischemia in rats. The product 500 mg/kg significantly reduced the ST segment elevation of electrocardiogram (P <0 01): Luotai 5mg/kg, 5 Both 0 mg/kg and 100 mg/kg significantly decreased serum CPK (P < 0.05, P <0 01). There was also a certain role in reducing the size of myocardial infarction, but there was no statistical significance. Luotai three dose group can significantly increase SOD activity (P <0 01), reduce MDA levels (P <0 05); this product 50mg/kg and 100mg/kg can also significantly increase the blood in myocardial ischemia PGI2 levels (P < 0.05) imply that Luotai’s protective effect on myocardial ischemia is related to anti-lipid peroxidation, and its promotion of PGI2 synthesis may be related to its anti-myocardial ischemia.