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目的通过比较五种疗法（生物反馈治疗法，包皮整形加埋线法，SSRIs法,中药法，安慰剂组）治疗前、后，盆底肌电反应图，血中5-羟色胺、儿茶酚胺，精浆中Mg2+、ACP、α-Glu、果糖值的变化，来观察盆底肌、神经递质、精浆等因素与早泄疗效的相关性。方法选取门诊PE患者符合标准者100例，采用生物反馈治疗法，包皮整形加埋线疗法，5-羟色胺再摄取抑制剂（SSRIs）疗法,中药疗法及安慰剂疗法五种方法，随机分组各20例进行治疗与干涉，通过监测：治疗前、治疗后4周、8周、12周各组盆底肌电反应图、血中5-羟色胺、儿茶酚胺、精浆中镁离子（Mg2+）、酸性磷酸酶（ACP）、α-葡萄糖苷酶（α-Glu）、果糖值，依结果分析各方法所影响的指标揭示盆底随意肌、阴茎敏感度、神经递质等对早泄的影响度以及如何组合才有长期疗效。结果在治疗第4周、8周、12周后：中药组、包皮整形加埋线组、SSRIs组、生物反馈治疗组，盆底肌电反应值与治疗前比较，具有明显的统计学意义（p<0.05）；血中5-羟色胺、儿茶酚胺值与各组治疗前比较，均具显著性差异（p<0.05）；各组精浆中镁离子（Mg2+）、酸性磷酸酶（ACP）、α-葡萄糖苷酶（α-Glu）、果糖值变化与治疗前比较，均具有明显的统计学意义（p<0.05）。结论各种治疗措施均可以不同程度影响早泄患者的性交时间：阴茎敏感度的改变对早泄具有一定的影响，不同的精浆成分对早泄具有不同的影响，神经递质的改变与早泄具有一定的相关性。但各疗法之间比较，无显著性差异。在延长性交时间的远期疗效方面，我们建议各种疗法综合治疗。“,” Objective: by comparing the five kinds of therapy (biological feedback therapy, foreskin plastic plus catgut embedding method, SSRIs method, traditional Chinese medicine, the placebo group) before and after the treatment, the EMG response, blood 5- serotonin, catecholamines, change in seminal plasma Mg2+, ACP, α-Glu, fructose values, correlation of pelvic floor muscle, neurotransmitter, seminal plasma factors of premature ejaculation effect.Methods: 100 cases of outpatient selected PE patients meet those standards, using biological feedback therapy, foreskin plastic plus catgut embedding therapy, 5- serotonin reuptake inhibitor (SSRIs) therapy, Chinese medicine therapy and placebo therapy in five methods, random group 20 patients were treated with interference, By monitoring: before treatment, after 4 weeks, 8 weeks, 12 weeks of pelvic floor electrical response, blood catecholamine, serotonin, 5- in seminal plasma magnesium ion (Mg2+), acid phosphatase (ACP), α - glucosidase (α -Glu), fructose, according to the results of each method. Sound indicators reveal pelvic voluntary, phalic susceptibility, neurotransmitter effects on premature ejaculation degree and how to combine it with long-term efficacy. Results: in the treatment of fourth weeks, 8 weeks, 12 weeks: the traditional Chinese medicine group, foreskin plastic plus catgut embedding group, SSRIs group, biofeedback treatment group, compared with before treatment of pelvic floor electrical response value, which was statisticaly significant (P < 0.05); compared with the groups before treatment 5- serotonin, catecholamine in blood, showed significant differences (P < 0.05); magnesium ion groups in the seminal plasma (Mg2+), acid phosphatase (ACP), α - glucosidase (α -Glu), fructose values compared with before treatment, were statisticaly significant (P < 0.05). Conclusion: various therapeutic measures can influence the patients with premature ejaculation sexual intercourse time: change the sensitivity of the penishas certain effect on premature ejaculation, seminal plasma components have different effects on premature ejaculation, premature ejaculation and neurotransmitter has certain correlation. But the comparison between each treatment, no significant difference. In the long-term efficacy extended sexual intercourse, we suggest that comprehensive treatment of various therapy.