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目的探讨控释地诺前列酮栓在促宫颈成熟中的临床效果。方法采用随机对照研究的方法,以无阴道分娩禁忌、足月妊娠、宫颈Bishop评分≤6分的初产妇160例为观察对象,采取自愿的原则,观察组60例采用阴道内放置控释地诺前列酮栓,对照组100例采用静脉滴注小剂量缩宫素,对比两组孕妇引产成功率及分娩结局。结果观察组置药后临产率、24 h阴道分娩率分别为98.33%、76.66%,明显高于对照组85.00%、10.00%(P均<0.05);剖宫产、产后出血、软产道裂伤、新生儿窒息率两组比较差异无统计学意义(P>0.05),宫缩过频过强为地诺前列酮栓的主要不良反应,研究组发生2例,但是取出该药后好转。结论控释地诺前列酮栓促宫颈成熟效果明显优于缩宫素,它是一种有效、方便、安全的促宫颈成熟和引产的药物,对母子无不良影响。
Objective To investigate the clinical effect of controlled release nitroprost suppository in promoting cervical ripening. Methods A randomized controlled study with no vaginal delivery taboo, full-term pregnancy, cervical Bishop score ≤ 6 points of primipara 160 cases of observation, the voluntary principle, the observation group of 60 patients were placed intravaginally controlled release Connaught Prostacyclin, the control group of 100 patients with intravenous infusion of small doses of oxytocin, compared the success rate of two groups of pregnant women, induction of labor and delivery outcomes. Results After treatment, the labor productivity and the vaginal delivery rate at 24 h were 98.33% and 76.66% in the observation group, significantly higher than those in the control group 85.00% and 10.00% (all P <0.05). Cesarean section, postpartum hemorrhage, , Neonatal asphyxia rate was no significant difference between the two groups was statistically significant (P> 0.05), uterine contractions too frequently as the main side effects of denominoprost suppository, the study group occurred in 2 cases, but after taking the medicine improved. Conclusions The controlled release noreprostone suppository is superior to oxytocin in promoting cervical ripening. It is an effective, convenient and safe method to promote cervical ripening and induction of labor, and has no adverse effect on the mother and the child.