1980年Leberc等发现,心得安可使肝静脉楔压和肝静脉游离压梯度明显降低,进而使门脉压力明显下降;还发现肝血流、心脏指数和心率亦明显减低。其对74例肝硬化上消化道出血患者作了预防再出血的治疗观察。用法为:心得安20～180毫克,每日2次,观察一年。结果服药组38例中仅1例复发,而安慰组36例中则有16例复发。一 In 1980, Leberc et al. Found that Enkapine significantly reduced hepatic venous wedge pressure and hepatic venous free gradient, which in turn significantly decreased portal pressure. Hepatic blood flow, cardiac index and heart rate were also significantly reduced. The 74 patients with cirrhosis of upper gastrointestinal bleeding were treated for the prevention of rebleeding. Usage is: the experience of 20 ~ 180 mg, 2 times a day, observe the year. Results In the medication group, only 1 of 38 patients relapsed, while in the comfort group of 36 patients, 16 patients relapsed. one