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1947年Sawyer等首先指出α-肾上腺素能受体阻断剂dibenamine能抑制兔排卵,并提出去甲肾上腺素(NE)与黄体生成素(LH)释放有关。随后有许多研究者报告过α-肾上腺素能受体阻断剂或去甲肾上腺素合成抑制剂也能抑制大鼠排卵和/或LH峰的出现。近来有人更进一步证明在大鼠第三脑室注射NE可诱发排卵和促性腺激素的释放。1970至1971年Kamberi等曾设想NE引起促性腺激素释放的效应可能并非直接作用于垂体前叶,而是通过丘脑下部释放的LHRH间接作用来实现。作者在本文中采用离体序列双室灌流系统检测了NE对丘脑下部中央基底部黄体生成素释放激素(LHRH)的释放和黄体生成素(LH)由垂体释放的影响。
In 1947, Sawyer et al. First pointed out that dibenamine, an alpha-adrenergic receptor blocker, inhibits rabbit ovulation and suggests that norepinephrine (NE) is associated with the release of luteinizing hormone (LH). Subsequently, many researchers reported that alpha-adrenergic receptor blockers or norepinephrine synthesis inhibitors can also inhibit ovulation and / or LH peak occurrence in rats. Recently, it was further demonstrated that injection of NE into the third ventricle of a rat can induce ovulation and release of gonadotropin. From 1970 to 1971, Kamberi et al. Assumed that the effect of NE-induced gonadotropin release may not be directly mediated by the anterior pituitary but rather indirectly through LHRH released from the hypothalamus. In this study, we used in vitro dual-chamber perfusion to determine the effects of NE on the release of LHRH and pituitary release from the basal portion of the hypothalamus.