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目的评价肺炎球菌疫苗及流感疫苗联合丙种球蛋白对支气管扩张合并感染的治疗作用。方法将2009年8月—2010年4月收治的50例支气管扩张合并感染患者随机分为对照组与治疗组各25例,对照组给予常规抗感染祛痰治疗,治疗组在常规治疗基础上给予丙种球蛋白2.5 g静脉滴注,每月1次,每位患者于肺部感染控制出院前注射肺炎球菌疫苗1次,并于我国流感高发季节前接种相应的灭活流感疫苗。两组患者均观察1年,对肺炎例数及住院次数、天数进行对比。结果治疗组住院次数与天数(分别为10人次、15 d)明显少于对照组(分别为20人次、28 d),与对照组比较肺炎发生例数明显减少且差异有统计学意义(P<0.05)。结论肺炎球菌疫苗及流感疫苗联合丙种球蛋白能提高支气管扩张特异及非特异性性免疫功能,明显减少支气管扩张感染。
Objective To evaluate the therapeutic effect of pneumococcal vaccine and influenza vaccine combined with gamma globulin on bronchiectasis complicated with infection. Methods Fifty patients with bronchiectasis and infection who were treated from August 2009 to April 2010 were randomly divided into control group and treatment group with 25 cases each. The control group was given routine anti-infective expectorant treatment. The treatment group was given conventional treatment Gg 2.5 g intravenously once a month. Each patient was given a pneumococcal vaccine one drop before pulmonary infection control discharge and the corresponding inactivated influenza vaccine was inoculated before the flu season in our country. Two groups of patients were observed for 1 year, the number of pneumonia cases and hospitalizations, the number of days were compared. Results The number of hospitalizations and the number of days in the treatment group were 10 and 15 days, respectively, which were significantly less than those in the control group (20 and 28 days, respectively). Compared with the control group, the incidence of pneumonia was significantly decreased and the difference was statistically significant (P < 0.05). Conclusions Pneumococcal vaccine and influenza vaccine combined with gamma globulin can enhance the specific and non-specific immune function of bronchiectasis and significantly reduce bronchiectasis infection.