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鬼白乙叉甙(VP-16-213)是一种相当有价值的抗肿瘤药物,已证明对人多种恶性肿瘤治疗效果良好。该药已被列为小细胞肺癌(SCLC)、睾丸肿瘤、Kaposi氏肉瘤等恶性病变初期联合化疗的一个主要组成部分;也已成为非小细胞肺癌(NSCLC)、卵巢癌、胃癌等一些其它肿瘤的重要二线药物或治疗方案的一部分。该药临床应用前景广阔。应进一步对其给药剂量、方式、时间,乃至与其它抗肿瘤药物的协同作用及该药代谢相关的物质等诸方面进行深入的研究。
Euonymus undulatus (VP-16-213) is a valuable anti-tumor drug that has proven to be effective against many human malignancies. The drug has been listed as a major component of the initial combined chemotherapy for small cell lung cancer (SCLC), testicular tumor, Kaposi’s sarcoma, and other malignant lesions; it has also become a non-small cell lung cancer (NSCLC), ovarian cancer, gastric cancer and other tumors Is part of an important second-line drug or treatment program. The clinical application of this drug is promising. Further study should be conducted on the dosage, mode, time, and even the synergistic effect with other anti-tumor drugs and substances related to the metabolism of the drug.