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目的研究ｂｃｌ－２、ｃ－ｅｒｂＢ－２、ｐ５３蛋白表达在胃癌发生中的作用。方法免疫组织化学方法。结果ｂｃｌ－２、ｃ－ｅｒｂＢ－２、ｐ５３蛋白表达阳性率分别为６０％、２２％和３８％。３种蛋白表达之间无显著相关性，且与胃癌临床病理参数亦无显著相关性。肠化组织ｂｃｌ－２表达阳性率为５３．３％。结论三种蛋白在胃癌的发生中可能起重要作用，检测３种蛋白表达可能有助于预测胃粘膜癌变
Objective To study the role of bcl-2, c-erbB-2 and p53 protein expression in gastric carcinogenesis. Methods Immunohistochemical methods. Results The positive rates of bcl-2, c-erbB-2 and p53 expression were 60%, 22% and 38%, respectively. There was no significant correlation between the three protein expressions, and there was no significant correlation with the clinicopathological parameters of gastric cancer. The positive rate of bcl-2 expression in intestinal metaplasia was 53.3%. Conclusion The three proteins may play an important role in the development of gastric cancer. The detection of the expression of three proteins may help predict gastric canceration.