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将DN患者216例,随机分为对照组(n=112),予口服降糖药物或胰岛素治疗;观察组(n=104),在降糖治疗的基础上给予前列地尔注射液10μg加入0.9%氯化钠注射液100ml中静脉滴注qd,14d为1个疗程。两组疗程均为14d。观察24小时尿微量白蛋白排协率(UAE)、视黄醇结合蛋白(RBP)、N-乙酰氨基葡萄糖苷酶(NAG)、β-半乳糖苷酶(GAL)等指标的变化。结果:对照组治疗后NAG、GAL、RBP略降低(P>0.05),而观察组更明显(P<0.05),两组UAE较治疗前明显降低(P<0.05)。观察组NAG、RBP较对照组明显降低(P<0.05)。结论:联合前列地尔治疗对糖尿病肾小管功能较单纯血糖控制更显著。
216 patients with DN were randomly divided into control group (n = 112), oral hypoglycemic drugs or insulin treatment; observation group (n = 104), on the basis of hypoglycemic treatment, alprostadil 10μg was added 0.9 % Sodium chloride injection 100ml intravenous qd, 14d for a course of treatment. Two groups of treatment are 14d. The changes of urinary albumin excretion rate (UAE), retinol binding protein (RBP), N-acetylglucosaminidase (NAG) and β-galactosidase (GAL) Results: The levels of NAG, GAL and RBP in the control group decreased slightly (P> 0.05), while those in the observation group were more obvious (P <0.05). The UAE of the two groups was significantly lower than that before treatment (P <0.05). The NAG and RBP in the observation group were significantly lower than those in the control group (P <0.05). Conclusion: The combination of alprostadil treatment more significantly than the control of diabetic renal tubular function alone.