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[期刊论文] 作者：Xiang-wei YUAN,Xiao-feng ZHU,Xiu-fang HUANG,Pu-yi SHENG,Ai-shan HE,Zi-bo YANG,Rong DENG,Gong-kan FENG,
来源：中国药理学报（英文版） 年份：2007
Aim:To determine whether intefferon-α (IFNα) can enhance doxorubicin sensitivity in osteosarcoma cells and its molecular mechanism. Methods:Cell viability was...
ATM-mediated phosphorylation of Beclin 1 and mitochondrial fission promote DNA damage-induced mitoph
[会议论文] 作者：Dan-Dan Li,Bao-Xia Li,Jian-Wei Jiang,Xiao-Qi Wu,Ting Sun,Wen-Dan Chen,Gong-Kan Feng,Xiao-shi Zhang,Xiao-Feng,
来源：2014医学科学前沿暨第三届个体化治疗与抗肿瘤药物研究新趋向研讨会 年份：2014
Mitophagy is a mitochondrial recycling process that primarily promotes cell survival,but can also cause cell death in the presence of prolonged injury.It has been suggested a direct relationship exist...
[会议论文] 作者：Xiao-Feng Zhu,Rui-Yan Wu,Peng-Fei Kong,Yun Huang,Liang-Ping Xia,Yun-Yun Tang,Zhi-Ling Li,Gong-Kan Feng,
来源：2019中国肿瘤学大会 年份：2019
...
Feedback loops blockade potentiates antitumor activity of a novel AKT1 inhibitor DC120 in human live
[会议论文] 作者：Fen Yang,Rong Deng,Xiao-Jun Qian,Xiao-Qi Wu,Juan Qin,Ting Sun,Gong-Kan Feng,Xiao-Feng Zhu,Shao-Hua Chang,
来源：2013医学前沿论坛暨第十三届全国肿瘤药理与化疗学术会议 年份：2013
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Feedback Loops Blockade Potentiates Antitumor Activity of a Novel AKT1 Inhibitor DC120 in Human Live
[会议论文] 作者：Fen Yang,Xiao-Feng Zhu,Rong Deng,Shao-Hua Chang,Xiao-Jun Qian,Xiao-Qi Wu,Juan Qin,Ting Sun,Gong-Kan Feng,
来源：2012医学科学前沿暨第二届个体化治疗与抗肿瘤药物研究新趋向研讨会 年份：2012
The serine/threonine kinase AKT is generally accepted as a promising anticancer therapeutic target.However,the relief of feedback inhibition and enhancement of other survival pathways often attenuate...
Feedback loops blockade potentiates antitumor activity of a novel AKT1 inhibitor DC120 in human live
[会议论文] 作者：Fen Yang,Rong Deng,Shao-Hua Chang,Xiao-Jun Qian,Xiao-Qi Wu,Juan Qin,Ting Sun,Gong-Kan Feng,Ke Ding,Xiao-Feng,
来源：2013医学前沿论坛暨第十三届全国肿瘤药理与化疗学术会议 年份：2013
The serine/threonine kinase AKT is generally accepted as a promising anticancer therapeutic target.However,relief of feedback inhibition and enhancement of other survival pathways often attenuate anti...
IAPs inhibitor APG-1387 inhibits nasopharyngeal carcinoma stem-like cells via promoting autophagic d
[会议论文] 作者：Yang,Xiao-Feng Zhu,Rong Deng,Wen-Dan Chen,Xiang-Qiang Zhang,Lin Jiao,Xuan Li,Rui-Yan Wu,Bo-Xia Li,Gong-Kan Feng,
来源：2014医学科学前沿暨第三届个体化治疗与抗肿瘤药物研究新趋向研讨会 年份：2014
Nasopharyngeal carcinoma (NPC) is a common malignancy in South China.Cancer stem cells (CSCs) are thought as the key players in the resistance to chemo-or radio-therapy.In this study, we found that th...
DC120, a novel AKT inhibitor, preferentially inhibits nasopharyngeal carcinoma cancer stem-like cell
[会议论文] 作者：Juan Qin,Shao-Hua Chang,Ke Din,Xiao-Feng Zhu,Jiao Ji,Rong Deng,Jun Tang,Fen Yang,Gong-Kan Feng,Wen-Dan,
来源：2014医学科学前沿暨第三届个体化治疗与抗肿瘤药物研究新趋向研讨会 年份：2014
Side population (SP) cells in human nasopharyngeal carcinoma (NPC) are known to be enriched for cancer stem-like cells (CSLCs) and are the main cause of drug-resistance and tumor metastasis.In this st...
[会议论文] 作者：Xiao-jun Qian,Wen-Dan Chen,Gong-Kan Feng,Xiao-Feng Zhu,Yun-tian Li,Yan Yu,Yang Fen,Rong Deng,Jiao Ji,,
来源：2014医学科学前沿暨第三届个体化治疗与抗肿瘤药物研究新趋向研讨会 年份：2014
Dual PI3K/mTOR(phosphatidylinositol 3-kinase/mammalian target of rapamycin) inhibitors are being evaluated clinically for the treatment of tumors with a hyperactivated PI3K/mTOR pathway.However, unexp...
Ubiquitin degradation of ULK1 by ERK1 and GSK-3β cooperatively attenuates mitophagy and promotes tum
[会议论文] 作者：Xiao-Qi Wu,Gong-Kan Feng,Yi-Xin Zeng,Xiao-Feng Zhu,Shan Jiang,Rong Deng,Jun Tang,Wen-Dan Chen,Jiao Ji,
来源：2014医学科学前沿暨第三届个体化治疗与抗肿瘤药物研究新趋向研讨会 年份：2014
The modulation of autophagy is an important component of tumor initiation and progression and ULK1 plays an essential role in macroautophagy and mitophagy.However, the precise regulatory signaling mec...
ATM-mediated PTEN phosphorylation promotes PTEN nuclear translocation and autophagy in response to D
[会议论文] 作者：Jing-Hong Chen,Gong-Kan Feng,Yi-Xin Zeng,Jian-Wei Jiang,Xiao-Feng Zhu,Peng Zhang,Wen-Dan Chen,Dan-Dan,
来源：2014医学科学前沿暨第三届个体化治疗与抗肿瘤药物研究新趋向研讨会 年份：2014
PTEN (phosphatase and tensin homolog deleted on chromosome 10), a tumor suppressor frequently mutated in human cancer, has various cytoplasmic and nuclear functions.PTEN translocates to the nucleus fr...
Polo-Like Kinase 1 phosphorylates and stabilizes KLF4 to promote tumourigenesis in nasopharyngeal ca
[会议论文] 作者：Hai-Liang Zhang,Yu-Hong Chen,Xue-Lian Xu,Yan Yu,Zhi-Ling Li,Xiao-Dan Peng,Yun Huang,Li-Huan Zhou,Gong-Kan Feng,
来源：2019中国肿瘤学大会 年份：2019
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