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A novel inhibitor of N6-methyladenosine demethylase FTO induces mRNA methylation and shows anti-canc
[期刊论文] 作者:Guoyou Xie,Xu-Nian Wu,Yuyi Ling,Yalan Rui,Deyan Wu,Jiawang Zhou,Jiexin Li,Shuibin Lin,Qin Peng,Zigang,
来源:药学学报(英文版) 年份:2022
N6-methyladenosine(m6A)modification is critical for mRNA splicing,nuclear export,stabil-ity and translation.Fat mass and obesity-associated protein(FTO),the first identified m6A demethylase,is critical for cancer progression.Herein,we devel......
Super enhancer inhibitors suppress MYC driven transcriptional amplification and tumor progression in
[期刊论文] 作者:Ya-Wei Yan,Shaojun Tang,Subha Madhavan,Weiyi Ni,Zhan-peng Huang,Wen Li,Weidong Ji,Huangxuan Shen,Shuibin Lin,
来源:骨研究(英文版) 年份:2018
INTRODUCTIONrnOsteosarcoma is the most common type of primary bone sarcoma that mostly occurs in teenagers and young adults.1 Osteosarcoma usually grows in the...
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