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[会议论文] 作者：Longzhen WANG,Yichao ZHENG,Wen ZHAO,Hongmin LIU,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
The status of histone lysine methylation regulates the gene expression.Lysine-sepcific demethylase(KDM),as one group of the histone modification regulators,has been characterized two distinct families...
Exploration of 5-cyano-6-phenylpyrimidin derivatives containing an 1,2,3-triazole moiety as potent F
[期刊论文] 作者：Liying Ma,Haojie Wang,Yinghua You,Chaoya Ma,Yuejiao Liu,Feifei Yang,Yichao Zheng,Hongmin Liu,
来源：药学学报（英文版） 年份：2020
Histone lysine specific demethylase 1 (LSD1) has become a potential therapeutic target for the treatment of cancer.Discovery and develop novel and potent LSD 1...
Discovery of [1,2,4]triazolo[1,5-a]pyrimidine derivatives as new bromodomain-containing protein 4 (B
[期刊论文] 作者：Shuai Wang,Dandan Shen,Lijie Zhao,Xiaohan Yuan,Jialing Cheng,Bin Yu,Yichao Zheng,Hongmin Liu,
来源：中国化学快报（英文版） 年份：2020
Targeting bromodomain-containing protein 4 (BRD4) has been proved to be an effective strategy for cancer therapy. To date, numerous BRD4 inhibitors and degrader...
Abrogation of USP7 is an alternative strategy to downregulate PD-L1 and sensitize gastric cancer cel
[期刊论文] 作者：Zhiru Wang,Wenting Kang,Ouwen Li,Fengyu Qi,Junwei Wang,Yinghua You,Pengxing He,Zhenhe Suo,Yichao Zheng,
来源：药学学报（英文版） 年份：2021
Targeting immune checkpoints such as programmed cell death protein 1(PD-1)and pro-grammed death ligand-1(PD-L1)have been approved for treating melanoma,gastric...
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