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Preclinical pharmacokinetics of TPN729MA, a novel PDE5 inhibitor, and prediction of human pharmacoki
[会议论文] 作者:GAO Zhi-wei,ZHONG Da-fang,
来源:2015年第一届药代动力学朝阳论坛 年份:2015
TPN729MA is a novel selective phosphodiesterase type 5 (PDE5) inhibitor.The preclinical PK of TPN729MA was studied in rats and dogs.Human clearance (CL) values of TPN729MA were predicted from various...
[会议论文] 作者:YU Jing-hua,DEGN Pan,ZHONG Da-fang,CHEN Xiao-yan,
来源:2015年第一届药代动力学朝阳论坛 年份:2015
The furan-containing compounds widely exist in food, herb, synthetic drugs and air pollution, and many of them are toxic.It was proposed that metabolic activation of furan ring was related to their in...
Fasiglifam (TAK-875) inhibits hepatobiliary transporters: a possible factor contributing to fasiglif
[会议论文] 作者:ZHONG Kan,LI Xiu-li,GUO Zi-tao,ZHONG Da-fang,CHEN Xiao-yan,
来源:2015年第一届药代动力学朝阳论坛 年份:2015
Fasiglifam (TAK-875), a selective G-protein-coupled receptor 40 agonist, was developed for the treatment of type 2 diabetes mellitus.However, its clinical development was terminated in phase Ⅲ clinica...
New Fragmentation Pathways for Cephalosporins by Electrospray Ionization Quadrupole Time-of-flight M
[期刊论文] 作者:Paul Fawcett,ZHONG Da-fang,ZHOU Hui,
来源:高等学校化学研究(英文版) 年份:2005
IntroductionrnCephalosporins are antibiotics of β-lactam family. They have a broad spectrum of antibiotic activity due to their ability to inhibit bacterial c...
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