EXCITOTOXICITY相关论文
Excess extracellular glutamate leads to excitotoxicity, which induces neuronal death through the overactivation of N-met......
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This study investigated the neuroprotective activity of red ginseng extract (RGE, Panax ginseng, C.A.Meyer) against kain......
Purposes Convincing data demonstrate that serine racemase(SR)and its product,D-serine contribute to excitotoxicity.A lin......
Achyranthes bidentata polypeptides prevent apoptosis by inhibiting the glutamate current in cultured
Glutamate-induced excitotoxicity plays a critical role in the neurological impairment caused by middle cerebral artery o......
目的 研究阿魏酸钠(SF)腹腔注射对妊娠晚期母小鼠谷氨酸单钠(MSG)灌胃诱导的仔鼠兴奋性毒性神经损伤修复的影响.方法 将妊娠17d小......
Nafamostat mesylate, an apparent soi-disant panacea of sorts, is widely used to anticoagulate patients undergoing hemodi......
Involvement of mitogen-activated protein kinase pathways in N-methyl-D-aspartate-induced excitotoxic
Previous studies have shown that mitogen-activated protein kinase (MAPK) signaling pathways are involved in N-methyl-D-a......
Basic fibroblast growth factor protects auditory neurons and hair cells from noise exposure and glut
The purpose of the present study was to determine protectivie effects of basic fibroblast growth factor (bFGF) on cochle......
目的 观察不同剂量氯胺酮对喹呆酸(QA)诱导的亨廷顿病(HD)大鼠纹状体损伤的保护作用.方法 将30只雌性SD大鼠随机分为3组,均予注射Q......
目的研究桂利嗪（Cin）对兴奋毒喹啉酸（QA）损伤的海马神经元是否有保护作用，并研究其相关机制，方法采用海马神经元原代培养，检测培养神经元......
NMDA(N-甲基-D-天冬氨酸)受体在缺血性脑卒中所致兴奋性神经元死亡中起重要作用,但NMDAR阻滞剂在临床上一直未能取得理想效果。相......
目的：利用原代培养的海马神经细胞，研究人参皂甙Rb3对谷氨酸兴奋性神经毒性的保护作用及有关机制。方法：采用原代培养的胚胎大鼠海马......
目的研究粉防己碱(Tet)对喹啉酸(QA)致大鼠拟痴呆模型学习记忆障碍的改善作用和脑保护作用.方法向大鼠双侧海马CA1区微量注射QA制......
目的观察还原型谷胱甘肽(reduced glutathione,GSH)与N-乙酰半胱氨酸(N-Acetylcysteine,NNAC)对不同浓度谷氨酸(glutamate,Glu)诱......
近年来随着对青光眼性视神经病变机制的深入研究,已证实兴奋性氨基酸与青光眼视网膜神经节细胞凋亡密切相关.21世纪青光眼的治疗模......
目的探讨谷氨酸(Glu)对体外培养的大鼠皮层神经细胞作用的量效关系及其毒性损害作用.方法原代培养新生SD大鼠(1 d)大脑皮层神经细......
目的主要观察母鼠经口给予谷氨酸单钠ig对仔鼠大脑皮层和海马神经元Bax和Bcl-2表达的改变,探讨谷氨酸的兴奋毒性作用;并观察鼠大脑......
兴奋性氨基酸受体的过度活化会导致神经元的兴奋性死亡,该过程与细胞内钙离子([Ca2+]i)稳态失调密切相关。谷氨酸兴奋毒性参与许多......
人N-甲基-D-门冬氨酸受体(NMDAR，NR)单克隆抗体MABN1具有明确的抗兴奋毒保护作用，但其机制不明．以MABN1和MK-801分别预处理海马细胞，拮......
目的：为明确谷氨酸对神经细胞有兴奋性和毒性作用。方法：选用具有较多N-甲基D-天门冬氨酸(NMDA)受体的海马作为研究对象，选用SD大鼠，给......
目的:探讨丙酮酸乙酯是否对谷氨酸诱导的新生大鼠小脑颗粒神经元具有保护作用及其作用机制。方法:体外原代培养新生7 d大鼠小脑颗......
目的:分析比较肌萎缩侧索硬化病人和神经系统正常的受试者脑脊液中的谷氨酸水平,以明确由谷氨酸介导的"兴奋毒性"是否在ALS的发病......
Glaucoma is a range of progressive optic neuropathies characterized by progressive retinal ganglion cell loss and visual......
