Excitability相关论文
Mechanisms of homeostatic plasticity promote compensatory changes of cellular excitability in response to chronic change......
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SK channels modulate the excitability and firing precision of projection neurons in the robust nucle
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Objective Hydrogen sulfide (H2S), an endogenous gaseotransmitter/modulator, is becoming appreciated that it may be invol......
Activation of GABAA receptors at axon initial segment suppresses action potential firing in neocorti
In addition to the distribution at somatodendritic compartments,GABAA receptors also express at the axon of excitatory p......
Up-regulation of belta4 subunit of large-conductance Ca2+-activated potassium channels contributes t
The large-conductance Ca2+-and voltage-gated K+channels or BK channels are ubiquitously expressed throughout the central......
Objective Retinal ganglion cells, output neurons of the retina, receive excitatory inputs from bipolar cells and inhibit......
Activation of ATP-sensitive potassium channels antagonize nociceptive behavior and hyperexcitability
Nociceptive responses to noxious stimuli are initiated at peripheral nociceptor terminals.Ion channels play a vital role......
A novel inhibition of martentoxin on neuronal BK channel subtype and functional modulation of neural
Martentoxin as a 37 residues peptidyl toxin was capable of blocking large-conductance Ca2+-activated K+ (BK) channels in......
Peptide hormone ghrelin enhances neuronal excitability by inhibition of Kv7/KCNQ channel via GHS-R1a
Ghrelin enhances neuronal firing in substantia nigra pars compacta (SNc) where excitability of dopaminergic neurons dete......
Ghrelin is an endogenous ligand of the growth hormone secretagogue receptor(GHS-R).Through affecting the electrical prop......
Voltage-gated potassium (Kv) channels regulate membrane excitability that defines the fundamental mechanism of brain fun......
A novel inhibition of martentoxin on neuronal BK channel subtype (α+β4) and functional modulation of
Martentoxin as a 37 residues peptidyl toxin was capable of blocking large-conductance Ca2+-activated K+ (BK) channels in......
For a long time,the ability of neurons to respond to an electrical shock with an action potential is a property referred......
The Regulation of Excitation and Secretion in the Neurosecretory Cells Dissociated from the Eyestalk
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Myoclonus dystonia syndrome (MDS) is an inherited movement disorder,and most MDS-related mutations have so far been foun......
Somatosensory stimulation suppresses the excitability of pyramidal cells in the hippocampal CA1 regi
The hippocampal region of the brain is important for encoding environment inputs and memory formation. However, the unde......
目的:研究δ-阿片受体表达和激活对钠通道1.2亚型的电流特性的影响.方法:用双电极电压钳技术,在δ-阿片受体和钠通道亚型1.2共表达......
Effects of rhubarb extracts on hyperexcitability of hippocampal CA1 neurons after fluid percussion i
Objective To investigate the effects of rhubarb extracts, i.e. rhein and emodin, on the neuronal hyperexcitability and s......
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,Pharmacological modulation of the voltage-gated neuronal Kv7/KCNQ/M-channel alters the intrinsic ex
The prefrontal cortex (PFC) critical for higher cognition is implicated in neuropsychiatric diseases,such as Alzheimer’......
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Background:Dysfunctional spinal circuit may play a role in the pathophysiology ofamyotrophic lateral sclerosis (ALS).The......
本文以螯虾细小神经轴突为标本,成功地应用双玻璃微电极进行细胞内刺激与电活动的记录。观察了细小神经轴突膜电生理和物理特性参......
How does anterior cruciate ligament reconstruction affect the functioning of the brain and spinal co
Objective:To examine the effect of anterior cruciate ligament(ACL)reconstruction on spinal-reflex and corticospinal exci......
采用电刺激，使大白鼠在体腓肠肌产生不同强度的连续运动，对肌肉表面肌电图的动态变化情况进行了观测，随收缩时间延长，各运动强度的腓肠......
本文以豚鼠离体心房肌为标本,研究了不同剂量蛇床子素对心房肌生理特性及对窦房结自律性的影响。结果表明:蛇床子素明显抑制左房肌......
目的在不同电刺激下观察不同刺激强度的电诱发听性脑干反应(electrical evoked auditory brainstem response,EABR)I波幅值的变化,......
本文应用透射电镜观察豚鼠面神经不同程度压榨性损伤后的面神经纤维髓鞘的病理变化。结果表明：改变面神经兴奋性不能单纯用轴突病理......
目的研究小圆肌无菌性炎症模型脊髓背根节（DRG）的电生理特征及该背根节内和上臂皮下组织神经递质P物质（SP）含量的变化，以解释小切口软组......
慢性压迫大鼠背根神经节（chronic compression of the dorsal root,ganglion,CCD）后,背根神经节细胞兴奋性升高,但引起神经元兴奋性......
目的：研究骨癌痛大鼠背根神经节（DRG）初级感觉神经元兴奋性的改变,探讨外周敏化在骨癌痛发生中的作用。方法：在雌性SD大鼠,采用胫骨骨......
目的比较不同原因所致的逼尿肌不稳定（detrusor instability,DI）在逼尿肌自身生理特性方面的改变.方法建立大鼠膀胱流出道梗阻（bladde......
教学评价是教学实践中的重要环节,其本质是教学过程的反馈活动.教学评价对提高教学质量、优化教学过程具有重要作用.选择恰当的评......
目的:研究克班宁(Cre)对豚鼠离体心房肌生理特性的影响.方法:常规离体器官实验法.结果:Cre能明显减少豚鼠右心房自律性活动,明显抑......
以H-H模型为研究对象，通过改变方程中表征神经元可兴奋性的参数。用数值分析的方法考察可兴奋神经元的动力学性质．结果表明。可兴奋......
