【摘 要】
：
CUL4B, a scaffold protein that assembles CRL4B ubiquitin ligase complex, participates in the regulation of a broad spectrum of biological processes.We here demonstrated a critical role of CUL4B in dri
【机 构】
：
Key Laboratory of Experimental Teratology,Ministry of Education,Institute of Molecular Medicine and
【出 处】
：
2014全球华人遗传学大会暨全国第十三次医学遗传学学术会议
论文部分内容阅读
CUL4B, a scaffold protein that assembles CRL4B ubiquitin ligase complex, participates in the regulation of a broad spectrum of biological processes.We here demonstrated a critical role of CUL4B in driving cell cycle progression.We showed that loss of CUL4B resulted in a significantly reduced cell proliferation and G1 cell cycle arrest that were accompanied by the upregulation of the CDK inhibitors p21 and p57.
其他文献
目的:妊娠期糖尿病(GDM)患者可能存在胎盘环境异常,进而造成一些胎盘结构改变,并影响胎盘发育和功能.因此,本研究旨在确定GDM胎盘中是否存在结构改变.设计:比较GDM及正常妊娠者的足月胎盘的超微结构变化.方法:本研究纳入10例GDM及10例正常对照,经过知情同意后分别取其足月妊娠胎盘,分别应用光学显微镜(light microscopy,LM)和投射电子显微镜(transmission elec
Mutations in PINK1 cause early onset familial Parkinsons disease (PD).PINK1 is accumulated on followed by recruiting parkin to the outer membrane of damaged mitochondria to promote mitophagy.Here, we
Background: Hearing loss is one of the most prevalent human birth defects.Genetic factors contribute to the pathogenesis of deafness.It is estimated that one-third of deafness genes have already been
Background Many genes that have been found to contribute to deafness are currently being studied.Some 80 non-syndromic hereditary deafness genes have been confirmed.Proteins associated with cochlear d
目的:本课题旨在观察ube2c在斑马鱼胚胎发育过程中的时空表达规律,并对其功能进行研究.方法:选择2hpf(受精后2h)、4hpf、 Shpf、12 hpf、 24 hpf、 48 hpf、 72 hpf、7dpf(受精后7d)的斑马鱼胚胎,进行Real-Time RCR、westem blot对ube2c在不同时间段的表达检测;对各时期胚胎进行整胚原位杂交,观察ube2c在斑马鱼不同时期胚胎中时
神经管畸形(Neural Tube Defects,NTD)、先天性心脏病(Congenital Heart Diseases,CHD)等均是我国发病率居前的重大出生缺陷.内在遗传因素在这些疾病的发生中占重要地位,如超过70％的NTD的发生可归于遗传因素.深入明确这些重大出生缺陷的遗传机制,建立产前基因筛查清单,是降低其发生率的重要因素.罕见相关家系一定程度上限制了通过家系研究发现致病的基因变异.
Methyl salicylate (MeSa) is a stress hormone released by plants under attack by pathogens or herbivores.MeSa has been shown to attract predatory insects of herbivores and repel pests.The neuromodulato
TDP-43 (TAR DNA Binding Protein 43) is a multifunctional DNA/RNA binding protein and a causal gene of Amyotrophic Lateral Sclerosis (ALS), a severe neurodegenerative disease.It is hypothesized that ab
目的:用人精子染色体方法,分析HCV感染者的精子染色体质量.方法:取6例丙肝患者精液,与300只金黄地鼠卵体外受精,2-细胞胚培养,染色体制备,观察精子染色体数目和结构.结果:分析HCV组精子染色体129套,精子染色体畸变率10.85％,数目畸变率6.20％,结构畸变率5.43％.对照组精子染色体151套,其中染色体畸变率5.96％,数目畸变率3.97％,结构畸变率3.31％.HCV组与对照组精子
Spinal muscular atrophy (SMA), the most frequent human congenital motor neuron degenerative disease, is caused by loss-of-function mutations in the highly conserved survival motor neuron gene SMN1.Mut