【摘 要】
:
CUL4B, a scaffold protein that assembles CRL4B ubiquitin ligase complex, participates in the regulation of a broad spectrum of biological processes.We here demonstrated a critical role of CUL4B in dri
【机 构】
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Key Laboratory of Experimental Teratology,Ministry of Education,Institute of Molecular Medicine and
【出 处】
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2014全球华人遗传学大会暨全国第十三次医学遗传学学术会议
论文部分内容阅读
CUL4B, a scaffold protein that assembles CRL4B ubiquitin ligase complex, participates in the regulation of a broad spectrum of biological processes.We here demonstrated a critical role of CUL4B in driving cell cycle progression.We showed that loss of CUL4B resulted in a significantly reduced cell proliferation and G1 cell cycle arrest that were accompanied by the upregulation of the CDK inhibitors p21 and p57.
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