【摘 要】
：
目的:妊娠期糖尿病(GDM)患者可能存在胎盘环境异常,进而造成一些胎盘结构改变,并影响胎盘发育和功能.因此,本研究旨在确定GDM胎盘中是否存在结构改变.设计:比较GDM及正常妊娠者的足月胎盘的超微结构变化.方法:本研究纳入10例GDM及10例正常对照,经过知情同意后分别取其足月妊娠胎盘,分别应用光学显微镜(light microscopy,LM)和投射电子显微镜(transmission elec
【机 构】
：
南京医科大学第一附属医院;连云港妇幼保健院 南京医科大学第一附属医院
【出 处】
：
2014全球华人遗传学大会暨全国第十三次医学遗传学学术会议
论文部分内容阅读
目的:妊娠期糖尿病(GDM)患者可能存在胎盘环境异常,进而造成一些胎盘结构改变,并影响胎盘发育和功能.因此,本研究旨在确定GDM胎盘中是否存在结构改变.设计:比较GDM及正常妊娠者的足月胎盘的超微结构变化.方法:本研究纳入10例GDM及10例正常对照,经过知情同意后分别取其足月妊娠胎盘,分别应用光学显微镜(light microscopy,LM)和投射电子显微镜(transmission electron microscopy,TEM)对胎盘的母胎交界面行形态学观察及比较.结果:通过LM观察,GDM者胎盘绒毛组织发现其结构有如下改变:胎盘基质水肿、合胞体结数量增加、绒毛间质纤维蛋白沉积增多.通过TEM观察发现了GDM者胎盘中存在明显的终末绒毛退化性超微结构的改变,包括:血管合体膜及其基底膜增厚、合体滋养成微绒毛减少甚至缺失、线粒体及内质网肿胀或结构完全破坏、合体滋养层高度空泡化.结论:GDM胎盘和对照胎盘相比,其超微结构存在明显差异,这种差异可能造成了GDM者胎盘屏障损坏及其功能受损.
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