An NPR-regulated Neural Circuit Mediates C.elegans Avoidance to the Plant Hormone Methyl Salicylate

来源 :2014全球华人遗传学大会暨全国第十三次医学遗传学学术会议 | 被引量 : 0次 | 上传用户:yztc_yztc
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Methyl salicylate (MeSa) is a stress hormone released by plants under attack by pathogens or herbivores.MeSa has been shown to attract predatory insects of herbivores and repel pests.The neuromodulators and neural circuits mediating the complex responses of these animals to MeSa remain to be defined.Here we found that the nematode Caenorhabditis elegans exhibits a strong avoidance toward MeSa, which requires the activities of two closely related neuropeptide receptor genes npr-1 and npr-2.Genetic analyses indicate that npr-1 and npr-2 act in the RMG inter/motor neurons and the AIZ interneurons, respectively, to synthetically regulate the MeSa avoidance behavior.
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