【摘 要】
:
A novel pH-sensitive microsphere composed of water-soluble CM-chitosan (carboxymethylated chitosan) and alginate mixed with Na2SO4 was developed for controlling sulforaphane delivery.Sulforaphane was
【机 构】
:
State laboratory of chemical resource engineering,Beijing University of Chemical Technology,Beijing,
【出 处】
:
The 6th International Conference on Separation and Technolog
论文部分内容阅读
A novel pH-sensitive microsphere composed of water-soluble CM-chitosan (carboxymethylated chitosan) and alginate mixed with Na2SO4 was developed for controlling sulforaphane delivery.Sulforaphane was proved as an effective anticancer agent both in vitro and vivo studies [1].Moreover,latest data has been proved that sulforaphane has a direct inhibitory action on colon cancer cells [2].In this study,all experiments were performed in aqueous medium at neutral environment.Preparation of the microspheres was reported [3].Release characteristics under different pH values of these microspheres were investigated.In addition,release of sulforaphane from test microspheres were studied both in simulated gastric and segmented intestinal media.At pH 1.2,release of the test microspheres with Na2SO4 was low (7.41%) while at pH 7.4.we found all the microspheres were bursted,which increased the release of sulforaphane to 81.53%.The results clearly suggested that the CM-chito san and alginate mixed with Na2SO4 could be a suitable polymeric carrier for sulforaphane delivery in the segmented intestine.
其他文献
Hybrid membranes of chitosan(CS)/poly(vinyl pyrrolidone)(PVP)/1,2-bis(triethoxysilyl) ethane(BTEE) were prepared via a sol-gel method for pervaporation [1-3].The membranes were characterized by Fourie
Ellagic acid is currently considered for use as a cancer chemopreventive drug.It has also been reported that EA can inhibit the mutagenicity and carcinogenicity in a wide range of mutagents [1-3].EA h
Recently,Korea and Japan have been investigating low-rank coal upgrading technology using solvent extraction.The solvent extraction is the technology to separate only combustible matters from low-rank
To compare the chemical composition of volatile oils in herbal pair Flos caryophylli-Wenyujin extracted by different polar solvents,petroleum ether,ethyl acetate,and ethanol were used in this work.The
Oximes are occurred usually as a mixture of Z-and E-isomers in nature and in preparation.Due to the interconversion of oximes [1,2],the Z-and E-isomers are difficult to be separated completely.In this
In recent years,ionic liquids (ILs) were widely used in the pretreatment of cellulose for the production of biofuel [1-3].In this study,IL 1-ethyl-3-methylimidazolium dimethylphosphate ([Emim][Me2PO4]
As a traditional Chinese medincine,Ramulus mori has lots of active compounds eg.flavonoids,stilbennoids etc [1-2].In order to separate and purify them from each other,former researchers generally chos
Benzoic acid and sodium benzoate,widely used as food preservative,have some destructive effect on the cytoplasm of microorganisms as well as human cells [1].Large amount of benzoic acid is released wi
CaCO3 is one of the most common heat exchanger fouling ingredients.To explore the mechanism of CaCO3 fouling [1],the adsorption process on carlbon steel is studied aim at several CaCO3 supersaturation
Metal-organic frameworks (MOFs) and covalent-organic frameworks (COF) have become a very hot topic in gas adsorption and separation,due to their high specific surface areas (SSA) (500~5600 m2 g-l),low