Although microRNAs(miRNAs)have been validated to play prominent roles in the occurrence and development of human bladder cancer(BC),alterations and function of many miRNAs in bladder cancer invasion a
To observe the changes of miRNA expression profiles in the brain of aging rats,and their relationship with the expression of learning and memory related genes,and the intervention effect of Reinforcin
Although D-ribose is reputedly a key “anti-aging nutrient” and provided as a supplement to elderly people to improve their health,no laboratories have reported that D-ribose is involved in the product
肠道病毒71型(EV71)属于小RNA病毒科肠道病毒属成员，作为手足口病(HFMD)主要病原体之一，严重威胁公共卫生安全与婴幼儿健康.目前尚无针对EV71感染的特效治疗药物和高效疫苗.EV71的非结构蛋白3C蛋白酶除了能切割病毒多聚蛋白前体，有利于病毒自身蛋白的成熟；还能切割多种宿主蛋白，导致宿主转录和翻译的抑制，有利于病毒逃避天然免疫，促进病毒复制.3C蛋白酶连接宿主与病毒的相互作用，使其成为理
泡沫病毒(foamy virus,FV)属于反转录病毒科泡沫病毒亚科,它在体外培养的细胞或组织中能引起强烈病变效应,但尚未有报道表明它能在天然宿主体内形成致病症状,仅潜伏感染并伴随宿主终身。原型泡沫病毒(prototypefoamy virus,PFV)作为唯一感染人类的泡沫病毒,已经发现数种宿主限制因子可以抑制PFV复制,但PFV感染对细胞基因表达的影响尚待全面深入研究。本实验室前期利用PFV感
Ganoderma lucidum is a rare Chinese traditional medicine which is beneficial to the mind and body,prolonging life used by Chinese medicine.Our previous study found that Ganoderma lucidum miR-01 entere
侵袭转移是恶性肿瘤的最重要的生物学特征。肿瘤细胞的旺盛生长使其对铁需求远大于正常细胞，所以螯合治疗成为一种重要治疗策略。铁螯合剂展示了良好抗肿瘤特性及抑制侵袭转移能力，但作用机理尚未充分阐明。二硫代甲酸衍生物是一类重要的铁螯合剂，能从铁蛋白中萃取铁。细胞增殖评估显示它对HepG2、HCT-116、CT26细胞的生长有较强的抑制作用；克隆形成实验获得相似结果；Balb/c小鼠移植瘤实验表明二硫代甲酸
Tumor chemo-and radiotherapy induces hematopoietic organ damage and reduces thrombocyte counts.Conventional platelet transfusion strategies or drug therapies are used to treat thrombocytopenia.However
MET overactivation is one of crucial bypass resistance mechanism in EGFR-mutant NSCLC patients.But the regulation mechanisms of MET are not wholly clear,it is necessary to further explore more informa
p21WAF1/CIP1 is a broad-acting cyclin-dependent kinase inhibitor.Its stability is essential for proper cell cycle progression and cell fate decision.Ubiquitylation by the multiple E3 ubiquitin ligases