Objective: Facial asymmetry was corrected by a routine two-jaw surgery which consists of Le Fort I osteotomy and bilateral ramus approach.However, outcomes treated by minimally invasive approach (MIA) were favorable.This is to suggest clinical feasibility and guideline of MIA in facial asymmetric patients.Methods: Five facial asymmetric patients (1 male, 4 females) treated by MIA were reviewed from 2006 to 2013.The maxillary excess or deficiency and canted occlusion were evaluated by clinical examination and routine X-ray films.Canted occlusion was corrected by skeletal anchorage system (SAS) or minor surgeries which include posterior maxillary segmental osteotomy (PMSO) and unilateral surgical assisted rapid palatal expansion (SARPE) on non-shift side.The mandible was first setback by sagittal split ramus osteotomy on the non-shift side only (USSO) and then, on the shift side (BSSO).Postoperative findings relating to facial symmetry and both temporo-mandibular joints were reviewed.