病例资料:STEPHEN,男,60岁,新西兰人.因"反复关节疼痛5年,关节疼痛反复加重3月"就诊,病程中血尿酸最高＞ 1000umol/L.查体:中度贫血貌,心肺听诊无异常.腹软,肝肋下3cm,质韧,脾超过前正中线,达脐下3cm,质硬,无压痛,左足第一跖趾关节红肿,压痛明显.既往骨髓纤维化病史14年,头痛3年,长期服用奇曼丁及对乙酰氨基酚片等药物止痛治疗,用量为常规剂量的3-4倍.目前服用中药治疗
Context aging is associated with the variation of hypothalamic-pituitary-gonadal axis hormones, but how aging affect these hormones and whether there has difference between aging men and women is not
Objective Osteoporosis is well known to be highly heritable.However, up to date, the findings from more than 20 genome-wide association studies (GWASs) only explained less than 6％ of genetic risks.Stu
Objective Type 2 diabetes mellitus (T2D), one of the most widespread endocrine disorders, is characterized by insulin resistance and relative insulin deficiency.Insuin resistance,typically present fro
Background Many epidemiological studies indicated that prolonged high iodine intake would lead to an elevation of serum thyrotrophin (TSH) level, but the mechanism is elusive.Type 2 iodothyronine deio
Objective To investigate the sensitivity and specificity of the different Growth hormone stimulation tests(GHSTs) in children with short stature, and the influence factors on peak growth hormone(GH) r
Aims/hypothesis Estradiol (E2) and progesterone (P＜/span＞4) have been reported to modulate glucose metabolism during pregnancy.In this study, we aimed to evaluate the role of TCF7L2, a key regulator o
Objective Glucocorticoids are administered in moderate and severe cases of subacute thyroiditis (SAT),providing markedly relief from fever and pain.To our knowlage, there have been no reports regardin
目的 明确miR-17～92在胰岛β细胞功能调控中的作用以及机理方法 1)通过Cre-loxp系统构建胰岛β细胞特异性敲除miR-17～92基因的基因工程鼠;常规监测小鼠代谢相关指标;测量基因敲除鼠在体和离体的胰岛素分泌情况;观察胰腺的组织形态学并定量计算β细胞数量、体积、质量,胰岛β细胞的凋亡、增殖能力;荧光定量RT-PCR检测胰岛细胞胰岛素合成分泌相关基因表达情况.Western实验检测PTE
目的:评估利格列汀在2型糖尿病合并冠状动脉疾病患者中的安全性和疗效方法:2型糖尿病(T2D)患者的冠心病(CAD)的发病率和死亡率升高.我们纳入一些随机、安慰剂(PBO)对照研究数据,对DPP-4抑制剂利格列汀(LINA)5 mg治疗CAD患者的患者安全性和疗效数据(采用SMQ查询"栓塞和血栓事件"定义)进行了考察.安全性分析集包括治疗持续时间≥12周的患者(19项试验;LINA,n=451;PB