【摘 要】
：
Type 1 diabetes (T1D) in both nonobese diabetic (NOD) mice and humans is an autoimmune disease resulting from selective demage of pancreatic β cells by autoreactive T lymphocytes.Autoreactive CD8+ T c
【机 构】
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第三军医大学基础部免疫教研室,全军免疫研究所
【出 处】
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中国免疫学会第九届全国免疫学学术大会
论文部分内容阅读
Type 1 diabetes (T1D) in both nonobese diabetic (NOD) mice and humans is an autoimmune disease resulting from selective demage of pancreatic β cells by autoreactive T lymphocytes.Autoreactive CD8+ T cells, that play a indispensable key role in initiation and progression of T1D, are recommended as ideal targets for the prevention of T1D using antigenor antigenic peptide(epitope)-based specific immunotherapy.Several studies suggested that the potential ability of altered peptide ligand (APL) to induce immune tolerance might be stronger than wild type self peptides.
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