INVOLVEMENT OF MITOCHONDRIAL ATP-SENSITIVE POTASSIUM CHANNELS AND MITOCHONDRIAL PERMEABILITY TRANSIT

来源 :第二十四届长城国际心脏病学会议、亚太心脏大会暨国际心血管病预防与康复会议(The 24th Great Wall Int | 被引量 : 0次 | 上传用户:luckybaisy
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Objectives To evaluate the cardioprotective effect of atorvastatin (Ator) via modulation of mitochondrial permeability transition pore (mPTP) through mitochondrial ATP-sensitive potassium channels (mitoKATP channels).Methods Sprague-Dawley rat hearts were Langendorff-perfused with Krebs-Henseleit (K-H) buffer and subjected to 30 min global ischaemia followed by 120 min of reperfusion.
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