Graphene is a unique material from many perspectives.It has significant applications in electronics and it is a strong contender to replace silicon in future solid-state devices.The development of new methodologies for producing highly pure graphene layers with tailored electronic properties that could be useful for technological applications in the field of nanoelectronics.In fact, graphene is a fundamental material for nanoengineering and nanomanipulation.By control modification of the graphene structure with foreign atoms could open new functional properties for designing graphene-based devices with dedicated properties.The surface and electronic properties of the pristine and doped graphene will be presented for the future development of graphene-based devices.In addition, we will also present the charge injection in few-layer graphene sheet by combining contact-mode atomic force microscopy (AFM) and scanning Kevin probe microscopy (SKPM) for the state-of-the-art Memory device applications.