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Thrombin binding aptamer(TBA) is a 15-mer DNA aptamer which was found by SELLEX screening technology.It adopts a chair-type antiparallel G-quartet structure and can specifically interact with thrombin,thus inhibiting blood coagulation of the enzyme activity.Isonucleoside(IsoNA) is a kind of nucleosides whose bases connect to the positions other than C-1 of glycosyl moiety.The local conformation will be changed when IsoNA,especially the L-IsoNA,was incorporated into TBA.