【摘 要】
：
Marine-derived actinomycetes are emerging as the most important new sources for novel drug discovery and have produced lots of secondary metabolites possess
【机 构】
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StateKeyLaboratoryofTropicalMarineBioresourcesandEcology.SouthChinaSeaInstituteofOceanology,ChineseA
【出 处】
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活性天然产物生物合成及合成生物学学术论坛
论文部分内容阅读
Marine-derived actinomycetes are emerging as the most important new sources for novel drug discovery and have produced lots of secondary metabolites possessing excellent bioactivities.Our findings demonstrate that marine-derived actinomycetes are rich in taxonomical diversity.Chemical investigations on marine-derived actinomycetes led to the discovery of a number of novel natural products,as exemplified by bisindole alkaloids with unprecedented spiro-rings,1 and indolosesquiterpenes with N-N-linked atropo-diastereomeric scaffolds.Herein we report our continuous efforts to discover novel natural products from marine-derived actinomycetes and the biosynthetic basis to construct such natural products,with a focus on diverse cyclization mechanisms,such as a reductive cyclization in xiamycin,a reductive cyclization in ikarugamycin,and spontaneous cyclization in heronamides.
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