【摘 要】
：
Objective: Human hepatocellular carcinoma (HCC) cells treated with transcatheter arterial chemoembolization (TACE)suffer from hypoxia and hyponutrition.The study aimed to investigate the cytotoxic act
【机 构】
：
Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education),Department of Int
【出 处】
：
22nd Asia Pacific Cancer Conference(第22届亚太抗癌大会)
论文部分内容阅读
Objective: Human hepatocellular carcinoma (HCC) cells treated with transcatheter arterial chemoembolization (TACE)suffer from hypoxia and hyponutrition.The study aimed to investigate the cytotoxic activities of commonly used anticancer drugs in vitro against HCC cell line (HepG2) in a hypoxic and hyponutritional culture medium (HHCM) simulating TACE.Methods: The cells were treated for 2, 4, 6, and 24 h with four degrees of HHCM, 5％ 10％, 25％, and 50％, respectively, to simulate TACE.Ten different drugs were used [epirubicin(EPI), cisplatin (DDP), mitomycin-C (MMC), oxaliplatin(OXA), hydroxycamptothecin (HCPT), 5-fluorouracil (5-FU),gemcitabine (GEM), docetaxel (DTX), thiotepa (TSPA), and pemetrexed disodium (PEM)].The cells were assessed using3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay.The combination of dual drug treatment for 24 h was also tested.
其他文献
Gastric cancer is approximately 10% of the total incidence rate of invasive cancer worldwide and is the second leading cause of cancer deaths.Despite of its declining incidence, gastric cancerremains
Objective: Eribulin is a non-taxane microtubule dynamics inhibitor.In a previous phase Ⅲ trial, eribulin demonstrated a statistically significant improvement in overall survival (OS)versus current tre
Objective: To evaluate the correlation between the dose-volume of cardiac substructures and acute cardiac toxicity in the setting of concurrent adjuvant trastuzumab and radiotherapy (RT) in HER-2 posi
Chromosome 11q13.5 containing RSF1 (HBXAP), a gene involved in chromatin remodeling, was amplified in several human cancers, including ovarian carcinoma.Our previous studies demonstrated the requireme
Gastric cancer is still one of the most important health issues in the world.Half of gastric cancer patients are in Eastern Asia.Although treatment modalities such as chemotherapy and radiotherapy hav
Colorectal cancer (CRC) is currently the fourth most common cause of cancer death worldwide.Approximately 50% of patients develop distant metastases in the liver, which is the most common site; approx
Diffuse large B-cell lymphoma (DLBCL) is one of the most common forms of adult non-Hodgkin lymphoma (NHL).The addition of rituximab to standard CHOP chemotherapy regimens results in an improved overal
Few detailed clinical reports have been presented concerning the perihepatic lymph node (LN) assessment of hepatocellular carcinoma (HCC).The present study aimed to evaluate the incidence, site, and e
TNM staging classification is the gold standard used to identify tumor Stage, direct treatment options, and determine the prognosis and efficacy of treatments.In October2009, the 7th UICC/AJCC TNM sta
Objective: RT is the preferred fertility-sparing procedure.Relative contraindication of size ≥2 cm was questioned.We reported our ART experience in patients with cervical malignancies describing the s