Silibinin inhibits the invasion and migration of human gastric cancer cell line SGC7901 via the inhi

来源 :The 14th Congress of Gastroenterology China(第十四届全国消化系病学术会议) | 被引量 : 0次 | 上传用户:m168471863
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Objective To investigate the effect of silibinin on p38MAPK pathway in the anti-metastatic mechanism.Methods P-38MAPK and p-p38MAPK protein were detected by Western blot in SGC7901 cells treated with silibinin.After the treatment of p38MAPK inhibitor (SB203580) with or without silibinin,the invasion and migration capacities of human gastric cancer cell line SGC7901 was observed by Transwell chamber.MMP-2 and MMP-9 were detected by Western blot.
其他文献
Objective To investigate the effectiveness of eradication of Helicobacter pylori on preventing metachronous gastric carcinoma after endoscopic resection of early gastric cancer, thus providing clinica
会议
Aims 5-HT1A receptors (HTR1As) of the central nervous system (CNS) was thought to be important in the pathogenesis of chronic stress related functional gastrointestinal disorders (FGIDs), but its pote
会议
Objective Epidemiological studies indicated that patients with chronic Helicobacter pylori (H.pylori) infection have an increased risk of developing type 2 diabetes mellitus, but the underlying mechan
会议
Aims Abnormalities of brain activity are thought to play important roles in the pathogenesis of viscerally hypersensitivity.The insula as one important center processing visceral sensory and regulatin
会议
Background and purpose Patients with type Ⅱ diabetes mellitus (DM) patients were known to have higher prevalence of gastroesophageal reflux disease (GERD) in the Western countries, but data on the imp
会议
Background MicroRNA-106b (miR-106b) is thought to be an oncogenic microRNA that promotes tumor growth and metastasis.The potential predictive value of miR-106b was studied in colonic cancer patients.M
会议
Objectives Several microRNAs (miRNA) have been implicated in H.pylori related gastric cancer (GC).However, the molecular mechanism of miRNAs in gastric cancer has not been fully understood.In this stu
会议
Background The association between Helicobacter pylori infection and gastric cancer has been identified recently.However, the underlying molecular mechanism remained largely unknown.Methods and result
会议
Aim To investigate and compare the efficacy and safety of percutaneous transhepatic biliary stenting (FTBS) using a one-or two-stage procedure and determine the predictive factors for the efficacious
会议
Objective To investigate the effect of silibinin on the invasion and migration in human gastric cancer cell line SGC7901 and its underlying mechanism.Methods Human gastric cancer cell line SGC7901 was
会议