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Objective To investigate the effect of silibinin on p38MAPK pathway in the anti-metastatic mechanism.Methods P-38MAPK and p-p38MAPK protein were detected by Western blot in SGC7901 cells treated with silibinin.After the treatment of p38MAPK inhibitor (SB203580) with or without silibinin,the invasion and migration capacities of human gastric cancer cell line SGC7901 was observed by Transwell chamber.MMP-2 and MMP-9 were detected by Western blot.