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  5. MiR-101 inhibits cell growth and tumorigenesis of Helicobacter pylori related gastric cancer by repr

MiR-101 inhibits cell growth and tumorigenesis of Helicobacter pylori related gastric cancer by repr

来源 :The 14th Congress of Gastroenterology China(第十四届全国消化系病学术会议) | 被引量 : 0次 | 上传用户：weixin1980
【摘 要】
：
Objectives Several microRNAs (miRNA) have been implicated in H.pylori related gastric cancer (GC).However, the molecular mechanism of miRNAs in gastric cancer has not been fully understood.In this stu
【作 者】
：
L.Li G.X.Zhang 
【机 构】
：
Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210
【出 处】
：
The 14th Congress of Gastroenterology China(第十四届全国消化系病学术会议)
【发表日期】
：
2014年5期
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Objectives Several microRNAs (miRNA) have been implicated in H.pylori related gastric cancer (GC).However, the molecular mechanism of miRNAs in gastric cancer has not been fully understood.In this study, we reported that miR-101 is significantly down-regulated in H.pylori positive tissues and cells and in tumor tissues with important functional consequences.Ectopic expression of miR-101 dramatically suppressed cell proliferation and colony formation by inducing G1-phase cell-cycle arrest.
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