Mobilization of epithelial mesenchymal transition genes distinguishes active from inactive lesional

来源 :The 14th Congress of Gastroenterology China(第十四届全国消化系病学术会议) | 被引量 : 0次 | 上传用户:chao19890103
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Background Ulcerative colitis (UC), is a chronic, relapsing, and debilitating idiopathic inflammation, with variable and complex pathophysiologies.Our objective was to elucidate patterns of gene expression underlying the progression of UC disease.Methods Single endoscopic pinch biopsies (n=41) were sampled at both active and inactive stages at the same site in individual UC patients and compared with each other and to non-IBD healthy controls.Gene expression results were validated by quantitative reverse transcriptase-PCR (QRT-PCR), and results at the protein level were validated by immunohistochemistry and western blot.
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