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Aim: The goal of the present study is to establish a novel dissolution mode using the consistent dissolution methodology to individualize the dissolution criteria of different pharmaceutical formulations.Based on this dissolution mode, the novel dissolution apparatus should be designed, and the individualized dissolution criteria need to be developed.The possibility of realization of in vitro-in vivo correlation (IVIVC) for pharmaceutical formulations based on the individualized dissolution methodology was investigated, which provides a theoretical basis for the further development of this dissolution mode.