Heart failure is an end point of several types of heart diseases.Diagnosis of heart failure depends on a combination of tests.The level of BNP serves as an important measurement for the degree of heart failure and is essential for monitoring the effectiveness of therapeutic treatment.However,the blood test for BNP alone has about 80% accuracy for heart failure diagnosis.The BNP protein has a relative short half life and the test for BNP requires a clinical laboratory.Novel biomarkers of heart failure will help to increase the accuracy of blood-test based diagnosis.Certain types of novel protein biomarkers will allow the development of convenient at home or in office tests for quick diagnosis of heart failure.