Acute ablation of double positive thymocytes induces up-regulation of intrathymic Foxn1 in mice

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Thymus provides the basic architecture for development of thymocytes.Although being sensitive to invasion,the thymus in adolescent is resilient after impairment.Intrathymic IL-22 has been proved to be a critical mediator for thymic regeneration after insult.However,intracellular mechanism that governs this program is still to be defined.
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