Omics Meet Systems Biology Discovery of A Critical Transition Stage from Nonalcoholic Hepatosteatosi

来源 :第三届原位电离质谱会议 | 被引量 : 0次 | 上传用户：g123s123

【摘要】

：

Diagnosis and management of nonalcoholic fatty liver disease (NAFLD) remain a clinical challenge, in particular, how to accurately differentiate nonalcoholic st

【作者】

：

尹慧勇

【机构】

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中科院上海生科院营养科学研究所

【出处】

：

第三届原位电离质谱会议

【发表日期】

：

2015年4期

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Diagnosis and management of nonalcoholic fatty liver disease (NAFLD) remain a clinical challenge, in particular, how to accurately differentiate nonalcoholic steatohepatitis (NASH) from hepatosteatosis.In this study, by exploiting collective fluctuations of the lipidomic data, we discovered a critical stage (termed pre-NASH) from steatosis to NASH in a mouse model of NAFLD based on dynamical network biomarker (DNB) theory.

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Omics Meet Systems Biology Discovery of A Critical Transition Stage from Nonalcoholic Hepatosteatosi

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