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Paclitaxel (PT)-induced neurotoxicity is a significant problem associated with successful treatment of cancers.Insulin-like growth factor-1 (IGF-1) has neurotrophic effects on dorsal root ganglion (DRG) neurons.Whether 1GF-1 has protective effects on DRG neurite growth, cell viability, neuronal apoptosis, and neuronal phenotypes and activates the extracellular signal-regulated protein kinase (ERK1/2) and the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathways in DRG neurons with PT-induced neurotoxicity is still unclear.