【摘 要】
:
Tumoral downregulation of the enzyme argininosuccinate synthase (ASS 1) results in an intrinsic dependence on extraceilular arginine for growth.This dependence is known as arginine auxotrophy.As sever
【机 构】
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Advisory Board ElexoPharm GmbH Germany
论文部分内容阅读
Tumoral downregulation of the enzyme argininosuccinate synthase (ASS 1) results in an intrinsic dependence on extraceilular arginine for growth.This dependence is known as arginine auxotrophy.As several tumors are arginine auxotroph such as hepatocellular, prostate, and renal cancer, and malignant melanoma depletion of arginine could be an attractive novel anti-cancer strategy.
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