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  5. MESP1 scales Canonical Wnt signalling to regulate human pluripotent stem cell cardiomyocyte differen

MESP1 scales Canonical Wnt signalling to regulate human pluripotent stem cell cardiomyocyte differen

来源 :北京细胞生物学会第四次会员代表大会暨2014年年会 | 被引量 : 0次 | 上传用户：RTTR123
【摘 要】
：
MESP1 is an important transcription factor that regulates heart development and is expressed transiently during early stage of cardiovascular differentiation in
【作 者】
：
Lin Wang Fengzhi Zhang Xi Chen Lufeng Bai Jie Na 
【机 构】
：
AllauthorsarefromCenterforStemCellBiologyandRegenerativeMedicine,SchoolofMedicineTsinghuaUniversity,
【出 处】
：
北京细胞生物学会第四次会员代表大会暨2014年年会
【发表日期】
：
2014年11期
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MESP1 is an important transcription factor that regulates heart development and is expressed transiently during early stage of cardiovascular differentiation in mouse and other model systems.To better understand its function during human cardiovascular differentiation,we generated a MESP1 reporter human embryonic stem cell line through transcription activator-like effector nuclease (TALEN) mediated homologous recombination.MESP1 reporter cells faithfully recapitulated the expression of endogenous MESP1 gene and displayed interesting dynamic gene expression pattern.
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