【摘 要】
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OBJECTIVE To study the neuroprotective effects and mechanism of ZY-1 (a derived compound from nicotine) on hippocampal slices insulted by glutamate, NaN3 or
【出 处】
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第十四届中国神经精神药理学学术会议
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OBJECTIVE To study the neuroprotective effects and mechanism of ZY-1 (a derived compound from nicotine) on hippocampal slices insulted by glutamate, NaN3 or H2O2 in vitro.METHODS Different types of models of brain injury in vitro were developed by glutamate 1 mmol· L-1, NaN3 10 mmol· L-1 or H2 02 2 mmol· L-1.After 30 min of preincubation with ZY-1 or nicotine, hippocampal slices were subjected to glu tamate, NaN3 or H2O2, then the tissue activities were evaluated by using the 2, 3, 5-triphenyltetrazolium-chloride method.
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